毛蕊花糖苷通过抑制 TLR4 减轻实验性脑出血的急性炎症损伤。
Verbascoside attenuates acute inflammatory injury in experimental cerebral hemorrhage by suppressing TLR4.
机构信息
Day Surgery Center, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China; Neurosurgery Clinical Medical Research Center of Sichuan Province, China; Academician (Expert) Workstation of Sichuan Province, China.
出版信息
Biochem Biophys Res Commun. 2019 Nov 19;519(4):721-726. doi: 10.1016/j.bbrc.2019.09.057. Epub 2019 Sep 19.
Cerebral hemorrhage (ICH) is a common cerebrovascular condition with high mortality, disability and recurrence rates. TLR4-mediated acute inflammatory injury plays a pivotal role in ICH. Verbascoside (VB) is an active component of multiple medicinal plants, and exerts neuroprotective effects in ischemic stroke by targeting the inflammatory response. However, the effects of VB on ICH and the underlying mechanisms remain unclear. In this study, we analyzed the therapeutic effects of VB on acute ICH, and the possible involvement of TLR4-mediated inflammation. VB improved the behavioral score and reduced the hematoma volume, brain edema and neuronal apoptosis in a murine model of acute ICH. Mechanistically, VB attenuated macroglia activation and decreased inflammatory factor levels, which in turn protected the neurons. Furthermore, TLR4 knockout abolished the effects of VB both in vivo and in vitro. Taken together, VB attenuates the symptoms of ICH by targeting the TLR4-mediated acute inflammatory response.
脑出血（ICH）是一种常见的脑血管疾病，具有高死亡率、高残疾率和高复发率。TLR4 介导的急性炎症损伤在 ICH 中起关键作用。毛蕊花糖苷（VB）是多种药用植物的活性成分，通过靶向炎症反应在缺血性中风中发挥神经保护作用。然而，VB 对 ICH 的影响及其潜在机制尚不清楚。在这项研究中，我们分析了 VB 对急性 ICH 的治疗作用，以及 TLR4 介导的炎症可能的参与。VB 改善了急性 ICH 小鼠模型的行为评分，减少了血肿体积、脑水肿和神经元凋亡。在机制上，VB 减弱了小胶质细胞的激活并降低了炎症因子的水平，从而保护了神经元。此外，TLR4 敲除消除了 VB 在体内和体外的作用。综上所述，VB 通过靶向 TLR4 介导的急性炎症反应来减轻 ICH 的症状。
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