可见光促进了烯烃和炔烃的氟烷基化反应，使用 2-溴苯酚作为催化剂。
Visible light promoted fluoroalkylation of alkenes and alkynes using 2-bromophenol as a catalyst.
机构信息
Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Zunyi Medical University, Zunyi 563003, China.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2019 Oct 8;55(81):12259-12262. doi: 10.1039/c9cc06587c.
We report a new protocol for the fluoroalkylation of alkenes and alkynes by using 2-bromophenol as a catalyst. This reaction can be tailored for different reaction modes by altering the base and solvent, which feature a wide substrate scope and excellent functional group tolerance with high chemo- and regioselectivities. We further propose a mechanism involving an electron donor-acceptor (EDA) complex.
我们报告了一种使用 2-溴苯酚作为催化剂对烯烃和炔烃进行氟烷基化的新方法。通过改变碱和溶剂，该反应可以针对不同的反应模式进行定制，具有广泛的底物范围和出色的官能团耐受性，以及高的化学和区域选择性。我们进一步提出了一种涉及电子给体-受体（EDA）络合物的反应机制。
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