Minh Nguyen Ngoc, Obara Hiromichi, Shimokasa Kenji, Zhu Junfang
Department of Mechanical Systems Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
Faculty of Industrial Technology, National University Corporation of Tsukuba University of Technology, Tsukuba, Ibaraki, Japan.
Biorheology. 2019;56(4):237-252. doi: 10.3233/BIR-190216.
Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied.
We investigated the stretching of bile and evaluated its extensional viscosity using a filament-breakup device.
A liquid bridge formed between the endplates of the filament-breakup device. The midpoint diameter of the bridge was recorded by a laser micrometer. The filament self-thinning was captured by a high-resolution, high-speed camera. We used the liquid bridge diameter to evaluate the extensional viscosity of bile.
All samples show shear-thinning and viscoelasticity. Bile sediment has much greater viscosity and stretches more than bile solution. Filament thinning takes a long time for bile sediment and a short time for solution. The global function for the mid-filament diameter can be used to predict the evolution of the filament diameter of the liquid bridge and the trend of the extensional viscosity of bile.
The extensional viscosity of bile is much greater than its shear viscosity. Because mucus concentration makes bile sediment more viscous than the solution, bile viscosity can increase sharply, thereby increasing risks of such diseases as gallstones and sludge buildup in the biliary system.
肝脏分泌的胆汁对于脂肪消化和维持体内平衡至关重要。尽管胆汁的流变学对其流动非常重要，但其拉伸粘度尚未得到研究。
我们使用细丝破裂装置研究了胆汁的拉伸并评估了其拉伸粘度。
细丝破裂装置的端板之间形成液桥。通过激光测微仪记录桥的中点直径。通过高分辨率高速相机捕捉细丝的自稀释过程。我们使用液桥直径来评估胆汁的拉伸粘度。
所有样品均表现出剪切变稀和粘弹性。胆汁沉淀物的粘度比胆汁溶液大得多，且拉伸程度更大。胆汁沉淀物的细丝变稀过程耗时较长，而溶液的则耗时较短。细丝中点直径的全局函数可用于预测液桥细丝直径的演变以及胆汁拉伸粘度的趋势。
胆汁的拉伸粘度远大于其剪切粘度。由于黏液浓度使胆汁沉淀物比溶液更粘稠，胆汁粘度会急剧增加，从而增加胆结石和胆道系统中形成淤渣等疾病的风险。
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