Folkert Kyra N, de Beaufort Heather, Bauman Nancy M
The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Division of Ophthalmology, Children's National Health System, Washington, DC, USA.
Ann Otol Rhinol Laryngol. 2020 Feb;129(2):191-194. doi: 10.1177/0003489419877428. Epub 2019 Sep 27.
Horner syndrome is described as the clinical triad of miosis, ptosis, and anhidrosis. In pediatric patients the condition may be congenital or acquired from neoplastic, infectious or traumatic conditions, including birth trauma. Most cases of pediatric Horner syndrome present first to a pediatric ophthalmologist however since the neural pathways involve the cervical sympathetic chain otolaryngologists should understand the pathophysiology to avoid delay in management of potentially malignant cases.
To aid otolaryngologists in recognizing and managing pediatric Horner syndrome by describing 3 unique cases from malignant, traumatic and/or congenital causes.
Case report of 3 pediatric patients with Horner syndrome presenting to our pediatric otolaryngology department.
Case #1 is 5-month-old female with ptosis and a left level II 1.5 cm neck mass. Magnetic resonance imaging showed the mass displacing the common carotid artery and excisional biopsy revealed a poorly differentiated neuroblastoma. Case #2 is a 9-year-old female with anisocoria appearing after suffering a severe playground injury. Case #3 is a 3-year-old-male who developed ptosis and anisocoria following re-excision of a recurrent cervical lymphatic malformation.
Pediatric Horner syndrome may be a benign finding that is easily overlooked but may reflect a serious underlying condition. Otolaryngologists should be aware of the pathophysiology and differential diagnosis, including malignant causes, to appropriately manage patients.
霍纳综合征被描述为瞳孔缩小、上睑下垂和无汗的临床三联征。在儿科患者中,这种情况可能是先天性的,也可能是由肿瘤、感染或创伤性疾病引起的,包括产伤。大多数儿科霍纳综合征病例首先由儿科眼科医生诊治,然而,由于神经通路涉及颈交感神经链,耳鼻喉科医生应了解其病理生理学,以避免延误对潜在恶性病例的处理。
通过描述3例由恶性、创伤和/或先天性原因引起的独特病例,帮助耳鼻喉科医生识别和处理儿科霍纳综合征。
报告3例到我院儿科耳鼻喉科就诊的患有霍纳综合征的儿科患者。
病例1为一名5个月大的女性,有上睑下垂和左侧II级1.5 cm颈部肿块。磁共振成像显示肿块使颈总动脉移位,切除活检显示为低分化神经母细胞瘤。病例2为一名9岁女性,在遭受严重的游乐场损伤后出现瞳孔不等大。病例3为一名3岁男性,在复发性颈部淋巴管畸形再次切除术后出现上睑下垂和瞳孔不等大。
儿科霍纳综合征可能是一个容易被忽视的良性表现,但可能反映了严重的潜在疾病。耳鼻喉科医生应了解其病理生理学和鉴别诊断,包括恶性病因,以便对患者进行适当的处理。