[胺碘酮所致视神经病变：一种罕见的副作用]
[Amiodarone-induced optic neuropathy: A rare side effect].
作者信息
Arcani R, Pellerey M, Rouby F, Gobin N, Scapin J, Chagny M, Arnould T, Ambrosi P, Gayet S, Micallef J, Villani P, Daumas A
机构信息
Service de médecine interne, gériatrie et thérapeutique, hôpital de la Timone, Aix-Marseille université, AP-HM, 264, rue Saint-Pierre 13385 Marseille, France.
Service d'ophtalmologie, hôpital de la Timone, Aix-Marseille université, AP-HM, 264, rue Saint-Pierre 13385 Marseille, France.
出版信息
Rev Med Interne. 2019 Dec;40(12):826-830. doi: 10.1016/j.revmed.2019.09.001. Epub 2019 Sep 24.
INTRODUCTION
The diagnosis of bilateral papilledema implies emergency medical care to look for intracranial hypertension and arteritic ischemic neuropathy. However, other causes must also be mentioned, including drugs. Too often underrated because of their usual benignity, drug side ophthalmological effects can be severe and are typically bilateral.
CASE REPORT
An 80-year-old woman was hospitalized for bilateral papilledema, predominantly in the left eye, with lowered visual acuity. After ruling out intracranial hypertension, arteritic ischemic optic neuropathy, non-arteritic, and inflammatory bilateral papilledema, the diagnosis was toxic optic neuropathy.
CONCLUSION
Bilateral edematous optic neuropathy is a known side effect of amiodarone, uncommon but to be known because of the large number of patients benefiting from this treatment.
引言
双侧视乳头水肿的诊断意味着需要紧急医疗护理以查找颅内高压和动脉炎性缺血性神经病变。然而，还必须提及其他病因，包括药物。药物性眼部副作用常常因其通常的良性特征而被低估，但其可能很严重且通常为双侧性。
病例报告
一名80岁女性因双侧视乳头水肿（主要为左眼）伴视力下降而住院。在排除颅内高压、动脉炎性缺血性视神经病变、非动脉炎性和炎性双侧视乳头水肿后，诊断为中毒性视神经病变。
结论
双侧水肿性视神经病变是胺碘酮已知的副作用，虽不常见，但鉴于有大量患者受益于该治疗，故应为人所知。
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