Department of Clinical Haematology, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, United Kingdom.
NIHR Oxford Biomedical Research Centre, Blood Theme, Oxford Centre for Haematology, Oxford University, Oxford, United Kingdom.
Semin Thromb Hemost. 2020 Feb;46(1):73-82. doi: 10.1055/s-0039-1697932. Epub 2019 Sep 28.
A severely injured patient presents several unique challenges to an admitting trauma team. Not only must the extent of the patient's injuries, particularly those that are life-threatening, be determined within minutes of hospital arrival, but also the trauma team needs to be able to assess whether the patient is bleeding and/or has an attendant coagulopathy. Early management of trauma patients is dictated by the presence (or absence) of significant bleeding. Standard definitive surgical procedures can be conducted in hemodynamically stable patients, but those in hemorrhagic shock should be treated according to damage control resuscitation (DCR) principles. DCR is a practice that has evolved over the last two to three decades, combining limited surgical techniques, which provide early hemorrhage control, and balanced transfusion resuscitation strategies, which mitigate (and ideally) treat trauma-induced coagulopathy (TIC). This review describes the contemporary perioperative management of trauma patients who have significant bleeding and/or TIC and sets out the evidence around the current approach for hemostatic resuscitation in these patients.
严重创伤患者给收治创伤团队带来了一些独特的挑战。不仅必须在患者到达医院后的几分钟内确定患者的受伤程度,特别是那些危及生命的受伤程度,而且还需要创伤团队能够评估患者是否有出血和/或伴随有凝血功能障碍。创伤患者的早期处理取决于是否存在(或不存在)大量出血。在血流动力学稳定的患者中可以进行标准的确定性手术,但对于出血性休克的患者,应根据损伤控制性复苏(DCR)原则进行治疗。DCR 是过去二三十年发展起来的一种实践,它结合了有限的外科技术,这些技术可以早期控制出血,以及平衡的输血复苏策略,这些策略可以减轻(并理想地治疗)创伤性凝血病(TIC)。这篇综述描述了有大量出血和/或 TIC 的创伤患者的围手术期管理,并阐述了目前针对这些患者止血复苏方法的证据。