恶性肿瘤中的高钙血症：用二氯亚甲基二膦酸盐（Cl2MDP）治疗。

Hypercalcemia in malignancies: treatment with dichloromethylene diphosphonate (Cl2MDP).

作者信息

Conte N, Di Virgilio R, Roiter I, Caberlotto L

出版信息

Tumori. 1985 Feb 28;71(1):51-4. doi: 10.1177/030089168507100109.

Abstract

Eleven hypercalcemic patients affected by various kinds of cancer were treated with dichloromethylene diphosphonate (Cl2MDP), 400 mg diluted in 500 ml of saline solution, i.v., during 3 h. Drug administration normalized plasma calcium levels in all treated patients, within 72 h for patients with lung cancer; within a longer period for other kinds of cancer. Moreover, Cl2MDP also reduced calciuria in treated patients. The use of the drug was not followed by side effects and was also well tolerated in patients with kidney insufficiency.

摘要

11名患有各种癌症的高钙血症患者接受了二氯亚甲基二膦酸盐（Cl2MDP）治疗，将400毫克药物稀释于500毫升盐溶液中，静脉滴注，持续3小时。给药后，所有接受治疗的患者血浆钙水平均恢复正常，肺癌患者在72小时内恢复正常；其他类型癌症患者恢复正常所需时间更长。此外，Cl2MDP还降低了接受治疗患者的尿钙排泄量。使用该药物未出现副作用，肾功能不全患者也能很好地耐受。