Effects of mono- and dialkylglucosides on the characterisation and blood circulation of lipid nanoemulsions.

Effects of two cosurfactants, -alkylglycosides with mono- or disaccharide groups - -nonyl -D-glucopyranoside (N-Glu) and -decyl -D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE). The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE > NG-LNE > Control-LNE. blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. The nature of high stability in saline solution and high affinity for serum albumin led to the prolonged circulation of LNE.