手性环戊二烯基铑/手性羧酸体系催化 8-烷基喹啉的亚甲基 C(sp3)-H 酰胺化反应的对映选择性
Catalytic Enantioselective Methylene C(sp )-H Amidation of 8-Alkylquinolines Using a Cp*Rh /Chiral Carboxylic Acid System.
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, 060-0812, Japan.
出版信息
Angew Chem Int Ed Engl. 2019 Dec 9;58(50):18154-18158. doi: 10.1002/anie.201911268. Epub 2019 Nov 11.
PMID:31593365
Abstract
Catalytic enantioselective directed methylene C(sp )-H amidation reactions of 8-alkylquinolines using a Cp*Rh /chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl-based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C-H bonds, which leads to the formation of C-N bonds with good enantioselectivity.
摘要
本文描述了使用 Cp*Rh/手性羧酸（CCA）杂化催化体系催化 8-烷基喹啉的催化对映选择性导向亚甲基 C(sp3)-H 酰胺化反应。基于联萘的手性羧酸能有效地区分不等价的亚甲基 C-H 键，从而形成具有良好对映选择性的 C-N 键。
Zotero 插件