Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Department of Internal Medicine, Dr. S N Medical College, Jodhpur, India.
Infect Disord Drug Targets. 2020;20(5):718-723. doi: 10.2174/1871526519666191008113616.
A number of patients of febrile thrombocytopenia increase during monsoon and postmonsoon period. Diseases like dengue fever, malaria, chikungunya fever, etc. are responsible for the clustering of febrile thrombocytopenia cases during this period. The diagnosis of fever with thrombocytopenia cases can be challenging and physicians should be aware of the regional and endemic seasonal cause of this syndrome.
It is a prospective observational study.
The study included 103 consecutive patients. The patients admitted with acute febrile illness defined by a duration of less than 2 weeks with thrombocytopenia were evaluated.
The present study included 103 consecutive cases of febrile thrombocytopenia. Out of these, 71.84% were male and 28.16% were female. The most common etiology for febrile thrombocytopenia was dengue fever (44.66%) and malaria (31.06%). Among clinical evaluation of the cases, fever was the inclusion criteria. Myalgia was the most common symptom found after fever, which was observed in 83.5% of the patients. The most common bleeding manifestation was petechiae/ purpura (12.62%) followed by hematuria (6.80%). Renal dysfunction was present in all 8(100%) cases of sepsis, followed by 14(43.75%) cases of malaria. All sepsis cases also had liver dysfunction, followed by 91.3% cases in dengue fever and 90.62 % cases in malaria had liver dysfunction.
The study showed that acute febrile thrombocytopenia is an important seasonal syndrome. The common causes are dengue fever and malaria. Early identification of these diseases and prompt treatment decreases complications and reduces mortality.
许多发热伴血小板减少症患者在季风期和季风后期增加。登革热、疟疾、基孔肯雅热等疾病导致这一时期发热伴血小板减少症病例聚集。发热伴血小板减少症病例的诊断具有挑战性，医生应了解该综合征在本地区和地方性季节性的病因。
这是一项前瞻性观察研究。
该研究纳入了 103 例连续患者。评估了患有急性发热性疾病（定义为病程小于 2 周伴血小板减少症）的患者。
本研究纳入了 103 例连续发热伴血小板减少症患者。其中 71.84%为男性，28.16%为女性。发热伴血小板减少症最常见的病因是登革热（44.66%）和疟疾（31.06%）。在对病例的临床评估中，发热是纳入标准。发热后最常见的症状是肌痛，观察到 83.5%的患者有此症状。最常见的出血表现是瘀点/瘀斑（12.62%），其次是血尿（6.80%）。所有脓毒症患者均存在肾功能不全，随后是疟疾患者的 14 例（43.75%）。所有脓毒症病例均有肝功能不全，随后是登革热病例的 91.3%和疟疾病例的 90.62%。
本研究表明，急性发热伴血小板减少症是一种重要的季节性综合征。常见病因是登革热和疟疾。早期识别这些疾病并及时治疗可减少并发症，降低死亡率。
