Goldberg L I
Clin Physiol Biochem. 1985;3(2-3):120-6.
Dopamine (DA) receptors have been divided into two subtypes: DA1 receptors which subserve vasodilation in renal, mesenteric, coronary, and cerebral vascular beds, and DA2 receptors which when activated cause inhibition of release of norepinephrine in sympathetic nerve endings. The subdivisions were made on the basis of differences in chemical structure and potency series of agonists and antagonists for the two receptor subtypes. Agonists and antagonists are now available which selectively act on DA1 or DA2 receptors. The clinical use of DA, DA pro-drugs, and selective DA agonists is discussed with particular emphasis on the treatment of congestive heart failure and hypertension. Finally, data are presented concerning possible relationships between peripheral DA1 and DA2 receptors and DA receptors classified in the central nervous system.
多巴胺（DA）受体已被分为两种亚型：DA1受体，它在肾、肠系膜、冠状和脑血管床中发挥血管舒张作用；DA2受体，其激活时会抑制交感神经末梢去甲肾上腺素的释放。这种分类是基于两种受体亚型的激动剂和拮抗剂在化学结构和效价系列上的差异。现在已有能选择性作用于DA1或DA2受体的激动剂和拮抗剂。本文讨论了多巴胺、多巴胺前体药物和选择性多巴胺激动剂的临床应用，尤其着重于充血性心力衰竭和高血压的治疗。最后，给出了有关外周DA1和DA2受体与中枢神经系统中分类的DA受体之间可能关系的数据。
