Salen/salan 金属配合物作为电化学适体传感器的氧化还原标记物。

Salen/salan metallic complexes as redox labels for electrochemical aptasensors.

机构信息

Université Perpignan Via Domitia, Biocapteurs-Analyses-Environnement, F-66860, Perpignan, France.

USR 3278 CRIOBE, PSL Research University, EPHE-UPVD-CNRS, Université de Perpignan Via Domitia, Laboratoire d'Excellence "CORAIL", Bâtiment T, 58 avenue P. Alduy, 66860 Perpignan, France.

出版信息

Chem Commun (Camb). 2019 Nov 4;55(85):12821-12824. doi: 10.1039/c9cc07575e. Epub 2019 Oct 9.

DOI:10.1039/c9cc07575e

PMID:31595908

Abstract

This work presents the synthesis and characterization of salen/salan metal complexes for their future application as electrochemical labels in affinity sensors. Due to its stability and electrochemical properties, an oxovanadium salan complex was selected and coupled to an estradiol-specific aptamer. The response of the resulting aptasensor was shown to decrease with increasing estradiol concentration.

摘要

本工作合成并表征了席夫碱/沙伦金属配合物，以期将其未来应用于亲和传感器中的电化学标记。由于其稳定性和电化学性质，选择了一种氧钒沙伦配合物并将其与雌二醇特异性适体偶联。结果表明，所得适体传感器的响应随雌二醇浓度的增加而降低。