Development. 2019 Oct 9;146(20):dev184721. doi: 10.1242/dev.184721.
Heart development in mammals is a beautifully complex process. Patterning, proliferation and differentiation are all coordinated with cell movements and tissue morphogenesis (for instance elongation, fusion, folding, looping). However, our knowledge of the molecular regulators of heart development currently outstrips what we know about the morphogenetic processes that create the functional structure. A new paper in Development seeks to understand tissue-level morphogenesis - and its molecular control - in the mouse secondary heart field. We caught up with first author Ding Li and his postdoctoral advisor Jianbo Wang, Associate Professor at the University of Alabama at Birmingham, to find out more about the paper.
哺乳动物的心脏发育是一个极其复杂的过程。模式形成、增殖和分化都与细胞运动和组织形态发生(例如伸长、融合、折叠、环化)协调一致。然而,我们目前对心脏发育的分子调控因子的了解超过了我们对创建功能结构的形态发生过程的了解。《发育》杂志上的一篇新论文旨在了解小鼠次级心脏场中的组织水平形态发生及其分子控制。我们采访了第一作者丁力和他的博士后导师、伯明翰阿拉巴马大学副教授 Jianbo Wang,以了解更多关于这篇论文的信息。