School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia.
Department of Physiology, College of Veterinary Medicine, Diyala University, Diyala, Iraq.
Cells. 2019 Oct 24;8(11):1314. doi: 10.3390/cells8111314.
Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood brain barrier (BBB), using pertussis toxin (PT), was assessed in mice. 0.2% CPZ(±PT) for 5 weeks produced oligodendrocytosis, demyelination and gliosis marked splenic atrophy (37%)
铜灰（CPZ）优先影响少突胶质细胞（OLG），导致脱髓鞘。为了研究中枢性少突胶质细胞增生和神经胶质增生是否引发适应性免疫反应，研究人员评估了在小鼠中联合使用标准（0.2%）或低（0.1%）剂量摄入 CPZ 并破坏血脑屏障（BBB），使用百日咳毒素（PT）的影响。5 周的 0.2% CPZ（±PT）导致少突胶质细胞增生、脱髓鞘和神经胶质增生，伴有脾脏明显萎缩（37%）。
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