存在水痘样疹时中度至重度银屑病的治疗

Treatment of Moderate-to-Severe Psoriasis in the Presence of Kaposi's Varicelliform Eruption.

作者信息

Campanati Anna, Molinelli Elisa, Brisigotti Valerio, Brancorsini Donatella, Bobyr Ivan, Diotallevi Federico, Radi Giulia, Offidani Annamaria

机构信息

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Institute of Pathological Anatomy and Histopathology, Polytechnic Marche University, Ancona, Italy.

出版信息

Case Rep Dermatol. 2019 Sep 23;11(Suppl 1):4-10. doi: 10.1159/000501992. eCollection 2019 Sep-Dec.

DOI:10.1159/000501992

PMID:31662732

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6816126/

Abstract

Kaposi's varicelliform eruption (KVE) is a disseminated cutaneous infection usually induced by herpesvirus type 1 or 2, vaccinia virus or Coxsackie A16 virus in a patient with an underlying dermatosis. Risk factors for KVE reported in the literature include erythroderma, systemic sepsis, therapy with immunosuppressants such as methotrexate and systemic steroids, and therapy with systemic retinoids. The occurrence of KVE in psoriasis is rare and it predominantly appears in patients affected by erythrodermic psoriasis during immunosuppressive treatment. We report our experience of a remarkable case of a patient affected by severe erythrodermic psoriasis and KVE that healed after antiviral treatment and after having received secukinumab. After 1 year, psoriasis was cleared and no recurrence of KVE had occurred.

摘要

卡波西水痘样疹（KVE）是一种播散性皮肤感染，通常由1型或2型疱疹病毒、牛痘病毒或柯萨奇A16病毒在患有潜在皮肤病的患者中诱发。文献报道的KVE危险因素包括红皮病、全身性败血症、使用甲氨蝶呤和全身性类固醇等免疫抑制剂治疗以及使用全身性维甲酸治疗。KVE在银屑病中很少见，主要出现在免疫抑制治疗期间受红皮病型银屑病影响的患者中。我们报告了一例严重红皮病型银屑病合并KVE患者的显著病例，该患者在抗病毒治疗和接受司库奇尤单抗后痊愈。1年后，银屑病消退，KVE未复发。