rs895819 与胃肿瘤风险的关联。

Associated of rs895819 with risk of stomach neoplasms.

机构信息

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Gene. 2020 Feb 5;726:144173. doi: 10.1016/j.gene.2019.144173. Epub 2019 Oct 26.

DOI:10.1016/j.gene.2019.144173

PMID:31669639

Abstract

A recent study published in GENE performed a meta-analysis on the relationship between genetic variant rs895819 in microRNA-27a and risk of stomach neoplasms, and the results indicated an association of rs895819 with increased risk of stomach neoplasms in heterogenous model among Chinese. However, the meta-analysis did not include one large sample size of study that met inclusion criteria. When including all related studies, our meta-analysis showed no significant association of rs895819 with stomach neoplasms risk in each different model in all population, Chinese and Europeans. Thus, pooling all related studies did not provide evidence on the association of rs895819 with increased risk of stomach neoplasms.

摘要

最近发表在《GENE》杂志上的一项研究对 microRNA-27a 基因变异 rs895819 与胃癌风险之间的关系进行了荟萃分析，结果表明 rs895819 与中国人群异质模型中胃癌风险增加相关。然而，该荟萃分析并未纳入符合纳入标准的一项大型样本量研究。当包括所有相关研究时，我们的荟萃分析显示 rs895819 与所有人群、中国人群和欧洲人群不同模型中的胃癌风险均无显著相关性。因此，汇总所有相关研究并不能为 rs895819 与胃癌风险增加相关提供证据。