Transfer of genetic information from T to B lymphocytes in the course of an immune response.

Lymphocytes carrying different allotypes were separated into B and T subpopulations and cultured in presence or in absence of U.V. inactivated Herpes simplex virus. The B lymphocytes cultured in presence of 1% of the supernatant collected from virus exposed T cells, synthesized an anti-herpetic antibody with some allotypic markers of the T cell donor.