Torun Yasemin Taş, Güney Esra, Aral Arzu, Büyüktaşkin Dicle, Tunca Hüseyin, Taner Yasemen Işik, İşeri Elvan
Child and Adolescent Psychiatry Department, Gulhane Education and Training Hospital, Turkey.
Child and Adolescent Psychiatry Department, Turkey.
Clin Psychopharmacol Neurosci. 2019 Nov 20;17(4):517-522. doi: 10.9758/cpn.2019.17.4.517.
The effect of vascular endothelial growth factor (VEGF) on neuronal development is known, but its relationship with attention deficit hyperactivity disorder (ADHD), a neurodevelopmental disorder, has not yet been fully elucidated. To our knowledge, this is the first human study investigating serum VEGF levels in ADHD patients. In this study, it has been aimed to compare serum VEGF levels between a healthy control group and in ADHD patients to help determine the association between serum VEGF levels and ADHD.
This study sample included forty-four patients diagnosed with ADHD and 43 healthy volunteer controls between 7 to 14 years old. Blood samples were taken from patients and the healthy control group to assess their serum VEGF levels. VEGF levels were calculated by subjecting the optical densities of the samples to concentrations of known standards as provided in the ELISA kit and then performing a regression correlation analysis.
The mean VEGF level of the children was 333.6 ± 209.8 in the ADHD group and 341.3 ± 201.8 in the control group. There were no statistically significant differences in serum VEGF levels between the ADHD and control groups ( = 926.000, = -0.170, = 0.865).
There was no significant difference in serum VEGF levels for untreated ADHD cases and a healthy control group. This is the first human study investigating serum VEGF levels in ADHD patients, so there is a need to replicate these findings.
血管内皮生长因子（VEGF）对神经元发育的影响已为人所知，但其与神经发育障碍注意力缺陷多动障碍（ADHD）的关系尚未完全阐明。据我们所知，这是第一项调查ADHD患者血清VEGF水平的人体研究。在本研究中，旨在比较健康对照组和ADHD患者的血清VEGF水平，以帮助确定血清VEGF水平与ADHD之间的关联。
本研究样本包括44名诊断为ADHD的患者和43名7至14岁的健康志愿者对照。从患者和健康对照组采集血样，以评估他们的血清VEGF水平。通过将样品的光密度与ELISA试剂盒中提供的已知标准浓度进行比较，然后进行回归相关分析来计算VEGF水平。
ADHD组儿童的平均VEGF水平为333.6±209.8，对照组为341.3±201.8。ADHD组和对照组之间的血清VEGF水平无统计学显著差异（=926.000，=-0.170，=0.865）。
未经治疗的ADHD病例和健康对照组的血清VEGF水平无显著差异。这是第一项调查ADHD患者血清VEGF水平的人体研究，因此需要重复这些发现。
