Division of Cardiology, Detroit Medical Center/Wayne State University, Detroit, MI, USA.
Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Acta Cardiol. 2020 Dec;75(8):695-704. doi: 10.1080/00015385.2019.1682337. Epub 2019 Nov 5.
The introduction of wearable cardioverter defibrillators (WCD) provides a novel means of protection in select patients at high risk for sudden cardiac death. The WCD can safely record and terminate life-threatening arrhythmias. In this review, we explore the data behind indications for WCD use and discuss its limitations. We searched PubMed, Google Scholar and Cochrane Central Register of controlled trials for relevant studies. The VEST trial, the first randomised controlled trial on WCD use, did not show statistical significance in utility of the WCD in post-myocardial infarction patients with low ejection fraction. While the use of WCD in this select patient population showed no benefit, the findings of the trial merit closer inspection. Various other indications of WCD use still exist and others require exploration. Select subsets of patients who stand to benefit for other indications include severely decreased left ventricular function post-revascularization with high arrhythmic burden, severe non-ischaemic cardiomyopathy, patients awaiting heart transplant and patients who have had their implantable cardioverter device temporarily removed. The role of the WCD is also being explored in children, peripartum cardiomyopathy, haemodialysis patients, and in syncope secondary to high-risk arrhythmias.
可穿戴式除颤器 (WCD) 的引入为某些高危心源性猝死患者提供了一种新颖的保护手段。WCD 可以安全地记录和终止危及生命的心律失常。在这篇综述中,我们探讨了 WCD 使用的适应证背后的数据,并讨论了其局限性。我们在 PubMed、Google Scholar 和 Cochrane 对照试验中心注册处搜索了相关研究。VEST 试验是第一项关于 WCD 使用的随机对照试验,结果并未显示 WCD 在射血分数低的心肌梗死后患者中的使用具有统计学意义。虽然在这种特定患者群体中使用 WCD 没有带来益处,但该试验的结果值得更仔细地研究。WCD 的其他各种适应证仍然存在,其他适应证仍有待探索。其他适应证中获益的特定患者亚组包括:再血管化后严重左心室功能下降伴高心律失常负担、严重非缺血性心肌病、等待心脏移植的患者和暂时移除植入式心脏复律除颤器的患者。WCD 的作用也正在儿童、围产期心肌病、血液透析患者以及因高危心律失常导致的晕厥中进行探索。