Wen Heling, Zhang Rui, Li Yajiao, Qian Hong, Yan Zhiguo, Chen Yu, Li Gang
Department of Cardiology, Hospital of The University of Electronic Science & Technology of China & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Department of Cardiovascular Surgery, The Seventh People's Hospital of Chengdu, Chengdu 610021, China.
Per Med. 2019 Nov;16(6):449-455. doi: 10.2217/pme-2018-0154. Epub 2019 Nov 6.
Conotruncal heart defects (CTDs) are the most common form of congenital heart disease. We investigated the association of these two single-nucleotide polymorphisms (SNPs) in the promoter of (rs353292 and rs4705343) with the susceptibility to CTDs in a Chinese population. Two SNPs in the promoter of (rs353292 and rs4705343) have been examined by PCR-RFLP methodology for 259 CTDs patients and 303 control subjects. An association between SNP rs4705343 of and CTDs has been confirmed in the Chinese Han population. Our results indicated that SNP rs4705343 in is a potential genetic marker for CTDs in the Chinese Han population.
圆锥动脉干心脏缺陷（CTDs）是先天性心脏病最常见的形式。我们在中国人群中研究了这两个位于[基因名称未给出]启动子区域的单核苷酸多态性（SNP，rs353292和rs4705343）与CTDs易感性之间的关联。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测了259例CTDs患者和303例对照者中[基因名称未给出]启动子区域的两个SNP（rs353292和rs4705343）。在中国汉族人群中已证实[基因名称未给出]的SNP rs4705343与CTDs之间存在关联。我们的结果表明，[基因名称未给出]中的SNP rs4705343是中国汉族人群CTDs的一个潜在遗传标志物。
Zotero 插件