Department of Dermatology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.
Scand J Immunol. 2020 Mar;91(3):e12846. doi: 10.1111/sji.12846. Epub 2019 Nov 24.
Psoriasis is a TNF-α/IL-23/IL-17A-mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A-producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.
银屑病是一种由 TNF-α/IL-23/IL-17A 介导的炎症性皮肤病，给患者造成了巨大的社会经济负担。产生 IL-17A 的免疫细胞，包括 Th17 细胞，是银屑病发展过程中的关键效应细胞。IL-17A 刺激表皮角质形成细胞产生 CCL20，最终将 CCR6+Th17 细胞招募到病变皮肤中。因此，CCL20/CCR6 轴作为一种驱动力，为富含 IL-17A 的皮肤环境做准备。在这篇综述中，我们总结了 CCL20/CCR6 轴的当前研究课题以及该轴对银屑病的治疗干预。
