CCL20 和 CCR6 轴在银屑病中的作用。
The CCL20 and CCR6 axis in psoriasis.
机构信息
Department of Dermatology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.
出版信息
Scand J Immunol. 2020 Mar;91(3):e12846. doi: 10.1111/sji.12846. Epub 2019 Nov 24.
Psoriasis is a TNF-α/IL-23/IL-17A-mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A-producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.
银屑病是一种由 TNF-α/IL-23/IL-17A 介导的炎症性皮肤病，给患者造成了巨大的社会经济负担。产生 IL-17A 的免疫细胞，包括 Th17 细胞，是银屑病发展过程中的关键效应细胞。IL-17A 刺激表皮角质形成细胞产生 CCL20，最终将 CCR6+Th17 细胞招募到病变皮肤中。因此，CCL20/CCR6 轴作为一种驱动力，为富含 IL-17A 的皮肤环境做准备。在这篇综述中，我们总结了 CCL20/CCR6 轴的当前研究课题以及该轴对银屑病的治疗干预。
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