在变性条件下检测长 DNA 序列中单核苷酸多态性的 DNA 开关。
A DNA Switch for Detecting Single Nucleotide Polymorphism within a Long DNA Sequence Under Denaturing Conditions.
机构信息
M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Department of Medicine, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
出版信息
Chemistry. 2020 Jan 13;26(3):568. doi: 10.1002/chem.201904777. Epub 2019 Nov 7.
Invited for the cover of this issue is the group of Yingfu Li at McMaster University. The image depicts a molecular switch for ultra-specific detection of DNA utilizing a guanine-quadruplex (up-right structure) resistant to denaturation by urea (ball-and-stick structures). Read the full text of the article at 10.1002/chem.201903536.
本期的封面特邀作者是麦克马斯特大学的李映福（Yingfu Li）课题组。该图片描绘了一种分子开关，可利用脲（棒状结构）抵抗变性的鸟嘌呤四链体（直立结构）进行超特异性 DNA 检测。全文请阅读 10.1002/chem.201903536。
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