Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
Ann Thorac Surg. 2020 Jun;109(6):1845-1849. doi: 10.1016/j.athoracsur.2019.09.041. Epub 2019 Nov 4.
Since the first reported use of prosthetic aortic grafts, infection has remained a feared complication. Pedicled omentum is the preferred flap in managing thoracic aortic graft infection (TAGI); however the literature is sparse. The authors present their experience with TAGI managed with pedicled omental flaps.
A single-institutional review from 2007 to 2018 was performed to analyze postoperative outcomes of omental flap reconstruction, performed by 2 surgeons, after a confirmed diagnosis of TAGI. The primary outcomes of overall complication rate, 30-day mortality, and in-hospital mortality were evaluated with univariate analysis.
Twenty patients requiring omental flap reconstruction after TAGI met inclusion criteria. The patient cohort included 14 men and 6 women with a mean age of 60.6 ± 12.9 years and a mean Charlson comorbidity index of 3.3 ± 2.1. Nine patients (45%) received omental flap reconstruction at the time of incipient TAGI surgical management by the cardiothoracic surgery team, whereas 11 patients received delayed reconstruction (mean, 6.22 days [range, 1-27]). The most common complications were graft leak (20%) and pseudoaneurysm (25%), with only 1 patient developing recurrent infection. Overall 30-day mortality was 20%. Chronic obstructive pulmonary disease and delayed omental flap reconstruction were associated with 30-day mortality (P = .04). Four of 11 patients (36.4%) who received delayed omental flap reconstruction died within 30 days, whereas 0 of 9 patients (0%) in the immediate omental coverage group died within 30 days (P = .043).
High mortality rates associated with TAGI exemplify the challenges associated with this disease process and patient population. Pedicled omentum is a safe adjunct with promising results to the management of TAGI while significantly reducing the risk of reinfection.
自首例人造主动脉移植物使用以来,感染一直是一种令人担忧的并发症。带蒂网膜瓣是治疗胸主动脉移植物感染(TAGI)的首选皮瓣;然而,文献资料很少。作者介绍了他们在经证实的 TAGI 患者中使用带蒂网膜瓣进行治疗的经验。
对 2007 年至 2018 年期间的单个机构进行了回顾性分析,以分析 2 位外科医生在确诊 TAGI 后进行网膜瓣重建的术后结果。采用单因素分析评估总体并发症发生率、30 天死亡率和住院死亡率等主要结局。
20 例需要在 TAGI 后进行网膜瓣重建的患者符合纳入标准。患者队列包括 14 名男性和 6 名女性,平均年龄为 60.6 ± 12.9 岁,平均 Charlson 合并症指数为 3.3 ± 2.1。9 例(45%)患者在心胸外科团队进行初始 TAGI 手术治疗时接受了网膜瓣重建,而 11 例患者接受了延迟重建(平均时间为 6.22 天[范围为 1-27 天])。最常见的并发症是移植物漏(20%)和假性动脉瘤(25%),只有 1 例患者发生复发性感染。总的 30 天死亡率为 20%。慢性阻塞性肺疾病和延迟网膜瓣重建与 30 天死亡率相关(P =.04)。在接受延迟网膜瓣重建的 11 例患者中,有 4 例(36.4%)在 30 天内死亡,而在立即网膜覆盖组中,没有患者在 30 天内死亡(P =.043)。
TAGI 相关的高死亡率表明了这种疾病过程和患者人群的挑战。带蒂网膜瓣是一种安全的辅助手段,对 TAGI 的治疗具有良好的效果,同时显著降低了再感染的风险。