Kishi K, Yasuda T, Ikehara Y
Department of Legal Medicine, Fukui Medical School, Japan.
Hum Hered. 1988;38(4):207-10. doi: 10.1159/000153786.
Polymorphism of alpha 2-HS-glycoprotein (AHSG) was revealed in human urine by isoelectric focusing and immunoblotting on polyacrylamide gels. More than 200 urine samples were examined in this manner and correct AHSG typing of the urine samples was achieved, in comparison with the results of direct grouping for plasma. Three phenotypes, AHSG 1, 2-1 and 2, were observed and found to be determined by two common alleles, AHSG1 and AHSG2. The frequencies of AHSG1 and AHSG2 calculated in a Japanese population were 0.7637 and 0.2363, respectively.
通过在聚丙烯酰胺凝胶上进行等电聚焦和免疫印迹,在人尿液中发现了α2-HS-糖蛋白(AHSG)的多态性。以这种方式检查了200多个尿液样本,并与血浆直接分组的结果相比,实现了尿液样本的正确AHSG分型。观察到三种表型,即AHSG 1、2-1和2,并发现它们由两个常见等位基因AHSG1和AHSG2决定。在日本人群中计算出的AHSG1和AHSG2的频率分别为0.7637和0.2363。