Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Division of Pathology, Tokushima University Hospital, Tokushima, Japan.
Anticancer Res. 2019 Nov;39(11):6025-6033. doi: 10.21873/anticanres.13808.
BACKGROUND/AIM: Carbohydrate antigen 19-9 (CA19-9) is a poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1α in IHCC. Here, we evaluated the expression and correlation of CA19-9 with HIF-1 and HDAC in IHCC.
This study included 62 patients with IHCC who underwent primary hepatectomy at our department. Clinicopathological characteristics were examined. Immunohistochemical expression of HIF-1 and HDAC1 in specimens was quantitatively evaluated.
Patients with high preoperative serum CA19-9 levels showed clinicopathological characteristics associated with tumour progression. High CA19-9 levels were associated with worse overall and recurrence-free survival. Univariate and multivariate analysis detected high CA19-9 levels as an independent poor prognostic factor for IHCC. Serum CA19-9 was significantly correlated with both HIF-1α and HDAC1 expression.
High serum CA19-9 level is a poor prognostic factor for overall survival in IHCC and correlates with HIF-1α and HDAC1 expression.
背景/目的：肿瘤相关抗原 19-9（CA19-9）是肝内胆管癌（IHCC）的不良预后标志物。先前的研究表明缺氧与癌症中的 CA19-9 之间存在关联，我们之前已经证明了在 IHCC 中 HDAC1 和 HIF-1α 之间存在相关性。在这里，我们评估了 CA19-9 与 IHCC 中的 HIF-1 和 HDAC 的表达和相关性。
本研究纳入了在我院接受原发性肝切除术的 62 例 IHCC 患者。检查了临床病理特征。对标本中 HIF-1 和 HDAC1 的免疫组织化学表达进行了定量评估。
术前血清 CA19-9 水平较高的患者具有与肿瘤进展相关的临床病理特征。高 CA19-9 水平与总生存率和无复发生存率较差相关。单因素和多因素分析均发现高 CA19-9 水平是 IHCC 的独立不良预后因素。血清 CA19-9 与 HIF-1α 和 HDAC1 表达显著相关。
高血清 CA19-9 水平是 IHCC 总生存率的不良预后因素，与 HIF-1α 和 HDAC1 表达相关。
