[正畸加载后牙龈中肌成纤维细胞的表达]
[Expression of myofibroblast in gingival after orthodontic loading].
作者信息
Meng Yao, Liu Man, Deng Qian-Nan
机构信息
Dept. of Orthodontics, Shenzhen Children's Hospital, Shenzhen 518000, China.
Medical Technic & Nursing School, Shenzhen Polytechnic, Shenzhen 518055, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2019 Oct 1;37(5):537-540. doi: 10.7518/hxkq.2019.05.016.
OBJECTIVE
To examine the expression of myofibroblast in gingival after orthodontic loading.
METHODS
Eight patients were selected as experimental group and treated with orthodontic force for 4 months. Ten patients were selected as the control group, were not loaded. The gingival protein expressions of collagen typeⅠ, collagen type Ⅲ, α-smooth muscle actin (α-SMA) were evaluated by immunohistochemistry method.
RESULTS
Positive expressions of collagen typeⅠ, collagen type Ⅲ were founded, while no positive staining for α-SMA in the gingival tissue except vascular epithelium before loading. In experimental group, collagen type I and collagen type Ⅲ were increased after orthodontic loading (P<0.05), the expression of α-SMA was detected and statistically significant (P<0.05).
CONCLUSIONS
The myofibroblast exists in gingival tissue after orthodontic loading, and it may be concerned with orthodontic teeth relapse.
目的
研究正畸加力后牙龈中肌成纤维细胞的表达情况。
方法
选取8例患者作为实验组，施以正畸力4个月。选取10例患者作为对照组，不施加力。采用免疫组织化学方法评估牙龈组织中Ⅰ型胶原、Ⅲ型胶原、α-平滑肌肌动蛋白（α-SMA）的蛋白表达。
结果
加载前牙龈组织中除血管内皮外，Ⅰ型胶原、Ⅲ型胶原呈阳性表达，α-SMA无阳性染色。实验组正畸加力后，Ⅰ型胶原和Ⅲ型胶原增加（P<0.05），检测到α-SMA的表达且具有统计学意义（P<0.05）。
结论
正畸加力后牙龈组织中存在肌成纤维细胞，其可能与正畸牙复发有关。
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