Martinez F D, Morgan W J, Wright A L, Holberg C J, Taussig L M
Department of Pediatrics, Arizona Health Sciences Center, Tucson 85724.
N Engl J Med. 1988 Oct 27;319(17):1112-7. doi: 10.1056/NEJM198810273191702.
In a prospective study of 124 infants enrolled as newborns, we assessed the relation between initial lung function and the subsequent incidence of lower respiratory tract illness during the first year of life. The risk of having a wheezing illness was 3.7 times higher (95 percent confidence interval, 0.9 to 15.5; P = 0.06) among infants whose values for total respiratory conductance (the reciprocal of the resistance to air flow of the entire respiratory system) were in the lowest third, as compared with infants with values in the upper two thirds of the range of values for the group. Boys with initial values in the lowest third for an indirect index of airway conductance had a 10-fold increase (95 percent confidence interval, 2.2 to 44.2; P = 0.001) in the risk of having a wheezing illness. A 16-fold increase (95 percent confidence interval, 1.7 to 147.1; P = 0.002) in the risk of having a wheezing illness was found among girls whose initial values for lung volume at the end of tidal expiration were in the lowest third. We conclude that diminished lung function is a predisposing factor for the development of a first wheezing illness in infants.
在一项对124名新生儿进行的前瞻性研究中，我们评估了初始肺功能与出生后第一年下呼吸道疾病后续发病率之间的关系。总呼吸传导率（整个呼吸系统气流阻力的倒数）值处于最低三分之一的婴儿发生喘息性疾病的风险比该组值处于最高三分之二的婴儿高3.7倍（95%置信区间为0.9至15.5；P = 0.06）。气道传导间接指标初始值处于最低三分之一的男孩发生喘息性疾病的风险增加了10倍（95%置信区间为2.2至44.2；P = 0.001）。潮气末肺容积初始值处于最低三分之一的女孩发生喘息性疾病的风险增加了16倍（95%置信区间为1.7至147.1；P = 0.002）。我们得出结论，肺功能降低是婴儿首次发生喘息性疾病的一个易感因素。
