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造血干细胞移植后他克莫司诱发糖尿病酮症酸中毒

Tacrolimus Induced Diabetic Ketoacidosis Following Hematopoietic Stem Cell Transplantation.

作者信息

Sharma Sanjeev Kumar, Doval Divya, Khandelwal Vipin, Kumar Meet, Choudhary Dharma

机构信息

Department of Hemato-Oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, 110005 India.

出版信息

Indian J Hematol Blood Transfus. 2019 Oct;35(4):711-713. doi: 10.1007/s12288-019-01113-w. Epub 2019 Mar 15.

DOI:10.1007/s12288-019-01113-w
PMID:31741624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6825099/
Abstract

Risk of diabetes mellitus increases after solid organ and hematopoietic stem cell transplantation. Diabetic ketoacidosis has been reported after solid organ transplantation in patients receiving tacrolimus but has rarely been reported after stem cell transplantation. The major risk factors for diabetic ketoacidosis are immunosuppressive drugs used after transplantation. We report here three cases of allogenic stem cell transplant who developed diabetic ketoacidosis while on treatment with tacrolimus. The drug was stopped in all the cases and patients were treated with insulin therapy resulting in complete recovery from diabetic ketoacidosis.

摘要

实体器官和造血干细胞移植后糖尿病的风险会增加。接受他克莫司治疗的实体器官移植患者中曾有糖尿病酮症酸中毒的报道，但干细胞移植后鲜有此类报道。糖尿病酮症酸中毒的主要危险因素是移植后使用的免疫抑制药物。我们在此报告3例接受同种异体干细胞移植的患者，他们在接受他克莫司治疗时发生了糖尿病酮症酸中毒。所有病例均停用了该药物，患者接受胰岛素治疗，糖尿病酮症酸中毒完全康复。

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本文引用的文献

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