早期胃癌切除术后生存率低：生存极值分析揭示了不同的基因组特征。
Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.
机构信息
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
Department of Surgery, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
出版信息
Br J Surg. 2020 Jan;107(1):14-19. doi: 10.1002/bjs.11443. Epub 2019 Nov 25.
Abstract
A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed.
摘要
尽管边缘阴性切除后，部分早期胃癌患者仍会出现早期复发和预后不良。本研究采用生存极限法，发现 TP53 热点突变与杂合性缺失同时发生与早期胃癌的意外不良预后相关。这种独特的基因组特征可能是完全切除的早期胃癌患者预后不良的新型生物标志物，需要进一步大规模验证。有前途的，需要验证。
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