Singular Research Centre in Chemical Biology and Molecular Materials, (CIQUS), Organic Chemistry Department, University of Santiago de Compostela (USC), 15782, Santiago de Compostela, Spain.
Chem Commun (Camb). 2019 Dec 17;56(1):46-49. doi: 10.1039/c9cc06644f.
We present the synthesis and transmembrane transport properties of a new family of tris-pyridine-decorated cyclic peptides. These molecules are designed to self-assemble into dimeric shuttles in nonpolar media, which act as symport ionophores in which, apparently, the tris-pyridine scaffold complexes both cations and anions with high potency and efficacy.
我们提出了一类新的三吡啶修饰环肽的合成及其跨膜转运性质。这些分子设计为在非极性介质中自组装成二聚体梭子，作为协同转运体离子载体，显然，三吡啶支架以高的效力和效价与阳离子和阴离子两者形成配合物。
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