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分级球囊房间隔造口术缓解犬先天性肺动脉高压:一例报告。

Graded balloon atrial septostomy for palliation of congenital pulmonary hypertension in a dog: A case report.

机构信息

VCA West Los Angeles, Los Angeles, California.

出版信息

J Vet Intern Med. 2020 Jan;34(1):283-288. doi: 10.1111/jvim.15666. Epub 2019 Nov 26.

Abstract

CASE DESCRIPTION

A 6-month-old intact female Maltese dog was presented for acute onset of syncope.

CLINICAL FINDINGS

The dog was presented for collapse upon excitement and exercise. It collapsed at discharge and suffered cardiopulmonary arrest. Echocardiography after resuscitation indicated severe pulmonary hypertension without evidence of intracardiac or extracardiac shunting. A presumptive diagnosis of congenital pulmonary hypertension was made.

TREATMENT AND OUTCOME

Initial treatment with sildenafil was effective at relieving syncope, but the extent of pulmonary hypertension as determined by serial echocardiography was unchanged. Graded balloon atrial septostomy was performed as a palliative procedure. Follow-up echocardiography identified a patent interatrial communication with bidirectional shunting. The dog remained asymptomatic 18 months after treatment.

CLINICAL RELEVANCE

To the best of our knowledge, this study is the first report in the veterinary literature of graded balloon atrial septostomy performed for therapeutic purposes. Further studies are required to determine if this palliative procedure is a beneficial treatment option for dogs with congenital or severe refractory pulmonary hypertension.

摘要

病例描述

一只 6 月龄未去势雌性马尔济斯犬因突发晕厥就诊。

临床发现

该犬兴奋或运动时易出现晕厥和倒地,出院时倒地后出现心肺骤停。复苏后的超声心动图检查提示严重肺动脉高压,但无心脏内或心脏外分流的证据。疑似先天性肺动脉高压。

治疗和预后

初始使用西地那非治疗晕厥有效,但多次超声心动图检查显示肺动脉高压程度无变化。进行分级球囊房间隔造口术作为姑息性治疗。后续超声心动图显示房间隔交通呈双向分流且开放。治疗后 18 个月,该犬无症状。

临床相关性

据我们所知,本研究是兽医文献中首次报道为治疗目的进行分级球囊房间隔造口术。需要进一步研究以确定该姑息性治疗方案是否对先天性或严重难治性肺动脉高压的犬有益。

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本文引用的文献

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Pulmonary Hypertension in Infants, Children, and Young Adults.婴幼儿及青少年肺动脉高压
J Am Coll Cardiol. 2017 May 23;69(20):2551-2569. doi: 10.1016/j.jacc.2017.03.575.
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Atrial Septostomy: A Contemporary Review.房间隔造口术:当代综述。
Clin Cardiol. 2015 Jun;38(6):395-400. doi: 10.1002/clc.22398. Epub 2015 Mar 2.

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