Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242, USA.
Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):97. doi: 10.1007/s11910-019-1012-1.
Systemic lupus erythematosus (SLE) is commonly associated with neurological manifestations. Rapid recognition and treatment of these complications may improve outcomes. In this article, we review the neurological conditions associated with SLE, their diagnosis and management strategies.
Recent meta-analysis showed that patients with neuropsychiatric manifestations of SLE were more likely to have positive antiphospholipid, antiribosomal P, and antineuronal antibodies. Another meta-analysis showed an association between SLE and antiphospholipid antibodies with cognitive impairment. Two large retrospective studies have shown that the peripheral nervous system is commonly involved in SLE frequently alongside the central nervous system. Neurological manifestations occur in most of SLE patients. Antiphospholipid antibodies are common in patients with SLE and increase the odds of neurological complications. Management typically involved a combination of treatments directed toward the neurological complication and therapies directed toward SLE itself. The efficacy of these treatment protocols, however, has not been rigorously studied and deserves further investigation.
系统性红斑狼疮（SLE）常伴有神经表现。快速识别和治疗这些并发症可能改善预后。本文综述了与 SLE 相关的神经疾病、其诊断和治疗策略。
最近的荟萃分析显示，有神经精神表现的 SLE 患者更可能出现抗磷脂、抗核糖体 P 和抗神经元抗体阳性。另一项荟萃分析显示 SLE 与抗磷脂抗体与认知障碍有关。两项大型回顾性研究表明，SLE 常累及周围神经系统，常与中枢神经系统同时受累。神经表现发生在大多数 SLE 患者中。抗磷脂抗体在 SLE 患者中常见，增加了神经并发症的几率。治疗通常包括针对神经并发症的联合治疗和针对 SLE 本身的治疗。然而，这些治疗方案的疗效尚未经过严格研究，值得进一步研究。
