Artru A A
Department of Anesthesiology, School of Medicine, University of Washington, Seattle 98195.
Anesthesiology. 1988 Oct;69(4):541-6. doi: 10.1097/00000542-198810000-00014.
The rate of cerebrospinal fluid (CSF) formation (Vf) and resistance to reabsorption of CSF (Ra) were determined in dogs at four doses of thiopental (6, 12, 18, and 24 mg.kg-1.h-1), midazolam (0.5, 1.0, 1.5, and 2.0 mg.kg-1.h-1), and etomidate (0.86, 1.72, 2.58, and 3.44 mg.kg-1.h-1). Results were compared within and between groups and to previously reported normal values for Vf (0.030-0.054 ml/min) and Ra (220-240 cmH2O.ml-1.min) in dogs. At the two lower doses of thiopental, midazolam, or etomidate Vf was not significantly different than previously reported normal values. At the two higher doses of each drug Vf was 0.019-0.024 ml/min, significantly reduced compared to Vf at the two lower doses of each drug. The pattern of Ra data was more varied. With thiopental Ra was elevated at the lowest dose, (354 +/- 17 cmH2O.ml-1.min, mean +/- SD) reduced at the highest dose (156 +/- 19 cmH2O.ml-1.min), and not significantly different than previously reported normal values at the two intermediate doses. With midazolam Ra was elevated at the lowest and highest doses (332 +/- 25 and 378 +/- 18 cmH2O.ml-1.min) and normal at the two intermediate doses. With etomidate Ra was normal at the three lower doses and reduced at the highest dose (187 +/- 13 cmH2O.ml-1.min). It is concluded that CSF volume may be increased and the CSF pressure at which CSF volume contracts may be increased by doses of thiopental or midazolam that increase Ra, but not increased by etomidate.
在犬类中，测定了硫喷妥钠（6、12、18和24毫克·千克⁻¹·小时⁻¹）、咪达唑仑（0.5、1.0、1.5和2.0毫克·千克⁻¹·小时⁻¹）以及依托咪酯（0.86、1.72、2.58和3.44毫克·千克⁻¹·小时⁻¹）四个剂量下的脑脊液（CSF）生成速率（Vf）和脑脊液重吸收阻力（Ra）。将组内和组间的结果与先前报道的犬类Vf（0.030 - 0.054毫升/分钟）和Ra（220 - 240厘米水柱·毫升⁻¹·分钟）的正常数值进行了比较。在硫喷妥钠、咪达唑仑或依托咪酯的两个较低剂量下，Vf与先前报道的正常数值无显著差异。在每种药物的两个较高剂量下，Vf为0.019 - 0.024毫升/分钟，与每种药物的两个较低剂量下的Vf相比显著降低。Ra数据的模式更为多样。硫喷妥钠在最低剂量时Ra升高（354 ± 17厘米水柱·毫升⁻¹·分钟，均值 ± 标准差），在最高剂量时降低（156 ± 19厘米水柱·毫升⁻¹·分钟），在两个中间剂量时与先前报道的正常数值无显著差异。咪达唑仑在最低和最高剂量时Ra升高（332 ± 25和378 ± 18厘米水柱·毫升⁻¹·分钟），在两个中间剂量时正常。依托咪酯在三个较低剂量时Ra正常，在最高剂量时降低（187 ± 13厘米水柱·毫升⁻¹·分钟）。得出的结论是，增加Ra的硫喷妥钠或咪达唑仑剂量可能会使脑脊液量增加，且脑脊液量收缩时的脑脊液压力可能会升高，但依托咪酯不会使其升高。
