日本慢性肝病患者的锌缺乏情况。
Zinc deficiency in patients with chronic liver disease in Japan.
作者信息
Ozeki Itaru, Arakawa Tomohiro, Suii Hirokazu, Tatsumi Ryoji, Yamaguchi Masakatsu, Nakajima Tomoaki, Kuwata Yasuaki, Toyota Joji
机构信息
Department of Hepatology, Sapporo Kosei General Hospital, Sapporo, Japan.
出版信息
Hepatol Res. 2020 Mar;50(3):396-401. doi: 10.1111/hepr.13465. Epub 2020 Jan 16.
AIM
This study aimed to determine the distributions of serum zinc levels and the prevalence of zinc deficiency in patients with chronic liver disease (CLD) in actual clinical practice, and to analyze the association between serum zinc levels and clinical characteristics.
METHODS
This study analyzed 1973 patients with CLD, including 749 with liver cirrhosis, who were admitted to Sapporo Kosei General Hospital in 2017.
RESULTS
Zinc deficiency, defined as a serum zinc level of <60 μg/dL, was observed in 555 patients overall (28.1%), including 182 (14.9%) patients without liver cirrhosis and 373 (49.8%) with liver cirrhosis. When marginal zinc deficiency was included, zinc deficiency (serum zinc level <80 μg/dL) was observed in 1594 (80.8%) patients overall, including 924 (75.5%) patients without liver cirrhosis and 670 (89.5%) with liver cirrhosis. Serum zinc levels were most strongly correlated with serum albumin levels. Of the 257 CLD patients with an albumin level of <3.5 g/dL, 234 (91.1%) had a serum zinc level of <60 μg/dL.
CONCLUSIONS
Zinc deficiency is common in patients with CLD. Serum zinc levels should be regularly measured, particularly in patients with liver cirrhosis.
目的
本研究旨在确定实际临床实践中慢性肝病（CLD）患者血清锌水平的分布及锌缺乏的患病率，并分析血清锌水平与临床特征之间的关联。
方法
本研究分析了2017年入住札幌厚生综合医院的1973例CLD患者，其中包括749例肝硬化患者。
结果
血清锌水平<60μg/dL定义为锌缺乏，总体上555例患者（28.1%）存在锌缺乏，其中无肝硬化的患者182例（14.9%），肝硬化患者373例（49.8%）。若将边缘性锌缺乏纳入，则总体上1594例患者（80.8%）存在锌缺乏，其中无肝硬化的患者924例（75.5%），肝硬化患者670例（89.5%）。血清锌水平与血清白蛋白水平的相关性最强。在257例白蛋白水平<3.5g/dL的CLD患者中，234例（91.1%）血清锌水平<60μg/dL。
结论
锌缺乏在CLD患者中很常见。应定期检测血清锌水平，尤其是肝硬化患者。
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