PET/CT 上 SUVmax 比值可区分肺转移和同时性多原发肺癌。
SUVmax Ratio on PET/CT May Differentiate Between Lung Metastases and Synchronous Multiple Primary Lung Cancer.
机构信息
Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing, China.
Department of Radiology, Beijing Chao-Yang Hospital, Beijing, China.
出版信息
Acad Radiol. 2020 May;27(5):618-623. doi: 10.1016/j.acra.2019.07.001. Epub 2019 Nov 29.
PURPOSE
To investigate the features of F-Fluoro-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) in differentiating synchronous multiple primary lung cancers (sMPLC) from intropulmonary metastasis (IM).
MATERIAL AND METHODS
Fifty-nine patients with two synchronous primary lung cancers were selected and 23 lung cancer patients with an additional solitary IM cancer were chosen as the control group between January 2009 and January 2019. Maximum standardized uptake values (SUVmax) on PET/CT was determined for each tumor. The SUVmax ratio between the two tumors was determined and receiver operating characteristic curve analysis was used to evaluate the diagnostic performance.
RESULTS
The difference of SUVmax ratio between sMPLC (2.3 ± 1.6) and IM (1.5 ± 0.4) was significant, p < 0.01; the area under the curve of the SUVmax ratio was 0.78 with the optimal cutoff value 1.7 (sensitivity 62.7% and specificity 82.6%, p < 0.001).
CONCLUSION
The SUVmax ratio between two tumors may be helpful in differentiating sMPLC from IM, independent studies with bigger size were needed to further confirm the findings.
目的
探讨氟-18-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）在鉴别同时性多原发性肺癌（sMPLC）与肺内转移（IM）中的作用。
材料与方法
选取 2009 年 1 月至 2019 年 1 月间 59 例同时性双原发性肺癌患者为观察组，23 例合并单发 IM 癌患者为对照组。测定 PET/CT 上每个肿瘤的最大标准摄取值（SUVmax）。测定两个肿瘤之间的 SUVmax 比值，并进行受试者工作特征曲线分析，评估诊断性能。
结果
sMPLC（2.3±1.6）与 IM（1.5±0.4）之间的 SUVmax 比值差异有统计学意义（p<0.01）；SUVmax 比值的曲线下面积为 0.78，最佳截断值为 1.7（敏感度为 62.7%，特异度为 82.6%，p<0.001）。
结论
两个肿瘤之间的 SUVmax 比值有助于鉴别 sMPLC 与 IM，需要进一步进行更大规模的独立研究来验证这些发现。
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