口腔鳞状细胞癌患者与有吸烟习惯但无癌症的受试者血清α-1抗胰蛋白酶水平的比较评估。
Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma.
作者信息
Ahuja Upasana S, Puri Nidhi, Bagewadi Anjana, Keluskar Vaishali, Ahuja Anshuman, Singh Harkanwal P
机构信息
Department of Oral Medicine and Radiology, I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India.
Department of Oral Medicine and Radiology, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
出版信息
J Family Med Prim Care. 2019 Nov 15;8(11):3657-3663. doi: 10.4103/jfmpc.jfmpc_571_19. eCollection 2019 Nov.
AIM/OBJECTIVES: To evaluate serum levels of Alpha-1 antitrypsin in patients with oral squamous cell carcinoma and compare them with that of healthy subjects with and without tobacco habits.
MATERIALS AND METHOD
The sample of 83 subjects was divided into three groups: 30 subjects with oral squamous cell carcinoma formed Group A. The age, sex, habit matched 23 healthy subjects with tobacco habit formed Group B and 30 healthy without history of consumption of tobacco formed Group C. Analysis of the samples was done using Alpha 1 antitrypsin kit and spectrophotometer.
RESULTS
There was a 2.33-fold rise in serum levels of Alpha 1 antitrypsin in Group A compared to Group B, 3.71-fold rise in Group A compared to Group C and 1.59-fold rise in Group B compared to Group C ( < 0.001). A definite rise in serum Alpha 1 antitrypsin levels in patients with oral squamous cell carcinoma as compared with healthy subjects with and without tobacco habits was observed.
CONCLUSION
Alpha1-antitrypsin can be used as an adjunct to various diagnostic procedures implied for the evaluation of oral squamous cell carcinoma.
目的
评估口腔鳞状细胞癌患者血清中α1抗胰蛋白酶水平，并将其与有吸烟习惯和无吸烟习惯的健康受试者进行比较。
材料与方法
83名受试者样本分为三组：30名口腔鳞状细胞癌患者组成A组。年龄、性别、习惯相匹配的23名有吸烟习惯的健康受试者组成B组，30名无吸烟史的健康受试者组成C组。使用α1抗胰蛋白酶试剂盒和分光光度计对样本进行分析。
结果
与B组相比，A组血清α1抗胰蛋白酶水平升高2.33倍；与C组相比，A组升高3.71倍；与C组相比，B组升高1.59倍（P<0.001）。观察到口腔鳞状细胞癌患者血清α1抗胰蛋白酶水平与有吸烟习惯和无吸烟习惯的健康受试者相比有明显升高。
结论
α1抗胰蛋白酶可作为评估口腔鳞状细胞癌的各种诊断程序的辅助手段。
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