24 小时尿钠与住院 2 型糖尿病患者蛋白尿的关系。

Association between 24-h urine sodium and proteinuria among hospitalized patients with type 2 diabetes.

机构信息

Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing 100044, China; Shijiazhuang Second Hospital, Hebei, Shijiazhuang 050000, China.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing 100044, China.

出版信息

J Diabetes Complications. 2020 Mar;34(3):107498. doi: 10.1016/j.jdiacomp.2019.107498. Epub 2019 Nov 29.

DOI:10.1016/j.jdiacomp.2019.107498

PMID:31813771

Abstract

AIMS

This study used estimated sodium intake from 24-h urine sodium (24hU) to explore the relationship of sodium intake with proteinuria among hospitalized patients with type 2 diabetes and with renal tubular injury markers [retinol-binding protein (RBP), beta 2-microglobulin (β-MG), N-acetyl-beta-D-glucosaminidase (NAG)].

METHODS

Hospitalized patients with type 2 diabetes (N = 269) were divided into two groups according to the median (0.08 g/day) 24-h urinary protein (24hU) level. Logistic regression was used to analyze the association between 24hU and 24hU ≥ 0.08 g/L; scatter plots were used to analyze the association of RBP, β-MG, and NAG with 24hU.

RESULTS

Overall, 269 patients with type 2 diabetes mellitus were enrolled (average age, 56 ± 12 years; men, 61.3%). Multivariate logistic regression analysis revealed a positive correlation between 24hU and 24hU ≥ 0.08 g/L; every 10 mmol of 24hU had an increased risk of 24hU elevation [odds ratio (OR) (95% confidence interval [CI]: 1.06 (1.01-1.11)]. Compared with the lowest quartile of 24hU, the highest quartile had an increased risk of 24hU elevation [OR (95% CI): 2.76 (1.25-6.05)]; 24hU did not correlate with RBP, β-MG, or NAG.

CONCLUSIONS

In hospitalized patients with type 2 diabetes, 24hU was independently related to 24hU ≥ 0.08 g/day However, no correlation of 24hU with RBP, β-MG, or NAG was found.

摘要

目的

本研究通过 24 小时尿钠（24hU）估计钠摄入量，探讨钠摄入量与住院 2 型糖尿病患者蛋白尿及肾小管损伤标志物[视黄醇结合蛋白（RBP）、β2-微球蛋白（β-MG）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）]之间的关系。

方法

根据 24 小时尿蛋白（24hU）中位数（0.08g/天）将 269 例住院 2 型糖尿病患者分为两组。采用 Logistic 回归分析 24hU 与 24hU≥0.08g/L 之间的关系；散点图分析 RBP、β-MG 和 NAG 与 24hU 的关系。

结果

共纳入 269 例 2 型糖尿病患者（平均年龄 56±12 岁；男性占 61.3%）。多因素 logistic 回归分析显示，24hU 与 24hU≥0.08g/L 呈正相关；24hU 每增加 10mmol，24hU 升高的风险增加[比值比（OR）（95%置信区间[CI]：1.06（1.01-1.11）]。与 24hU 的最低四分位数相比，最高四分位数 24hU 升高的风险增加[OR（95%CI）：2.76（1.25-6.05）]；24hU 与 RBP、β-MG 或 NAG 无相关性。