复发性阿弗他口腔溃疡患者的 5-羟色胺转运体基因（SLC6A4）变异性。
Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis.
机构信息
Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic; Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno 656 91, Czech Republic.
出版信息
Arch Oral Biol. 2020 Feb;110:104628. doi: 10.1016/j.archoralbio.2019.104628. Epub 2019 Dec 3.
OBJECTIVE
The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls.
DESIGN
Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis.
RESULTS
No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49).
CONCLUSIONS
Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
目的
本研究旨在探讨复发性阿弗他口炎（RAS）患者 SLC6A4 基因中的 5 种多态性。
设计
本病例对照研究共纳入 239 名受试者：86 名 RAS 患者和 153 名健康个体通过聚合酶链反应（PCR）联合/不联合限制性分析，对 SLC6A4 基因中的 5-羟色胺转运体长度多态性区域（5-HTTLPR）多态性、可变数串联重复（STin2）和单核苷酸多态性（rs25531、rs3813034、rs1042173）进行基因分型。
结果
未发现 RAS 患者与健康对照组之间所有研究多态性的等位基因或基因型频率存在显著差异（P > 0.05）。然而，单体型分析发现 RAS 患者中 LA12（HTTLPR、rs25531、STin2）单体型的频率高于健康对照组（P < 0.05，OR = 1.63，95%CI = 1.07-2.49）。
结论
本研究表明 SLC6A4 与捷克人群 RAS 的易感性之间可能存在关联。
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