氯毒素在癌症诊断与治疗中的当前生化应用及未来前景

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics.

作者信息

Khanyile Sbonelo, Masamba Priscilla, Oyinloye Babatunji Emmanuel, Mbatha Londiwe Simphiwe, Kappo Abidemi Paul

机构信息

Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.

Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.

出版信息

Adv Pharm Bull. 2019 Oct;9(4):510-520. doi: 10.15171/apb.2019.061. Epub 2019 Oct 24.

DOI:10.15171/apb.2019.061

PMID:31857956

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6912174/

Abstract

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and the possibility of conjugating this peptide to nanoparticles have enabled its diverse use in various biotechnological and biomedical applications for cancer treatment, such as in tumor imaging and radiotherapy. Because of the fascinating biological properties CTX possesses, elucidating its mechanism of action may hold promise for the development of new and effective therapeutic drugs, as well as more sensitive and highly specific cancer-screening kits. This article therefore reviews the currently known applications of CTX and suggests diverse ways in which it can be applied for the design of improved drugs and diagnostic tools for cancer.

摘要

氯毒素（CTX）是一种由36个氨基酸残基组成的微小4 kDa蛋白质，因其与脊柱和脑胶质瘤肿瘤的氯离子通道及基质金属蛋白酶-2（MMP-2）具有结合亲和力而广为人知。这种特性以及将该肽与纳米颗粒结合的可能性，使其在癌症治疗的各种生物技术和生物医学应用中得到了广泛应用，例如肿瘤成像和放射治疗。由于CTX具有迷人的生物学特性，阐明其作用机制可能为开发新型有效治疗药物以及更灵敏、高特异性的癌症筛查试剂盒带来希望。因此，本文综述了CTX目前已知的应用，并提出了多种将其应用于设计改进型癌症药物和诊断工具的方法。