de Oliveira Frederico Minardi, Bunhak Élcio José, Dos Santos Leandro Freire, Barros Priscila Debastiani, Cavalcanti Osvaldo Albuquerque
Universidade Estadual do Oeste do Paraná, Laboratório de Tecnologia Farmacêutica, Cascavel, Paraná, Brazil.
Universidade Estadual do Centro-Oeste, Departamento de Farmácia, Guarapuava, Paraná, Brazil.
Heliyon. 2019 Dec 19;5(12):e03053. doi: 10.1016/j.heliyon.2019.e03053. eCollection 2019 Dec.
This research aimed to analyse the influence of the incorporation of α-gluco-oligosaccharide (GOS-α) in the formation of isolated films of different combinations of polymethyl by applying physicochemical analyses such as Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG) and scanning electron microscopy (SEM). Polymer films were prepared by evaporation associating Eudragit® RS30D with α-GOS. FTIR results confirmed the incorporation of α-GOS. The intermolecular interaction involving carbonyl and hydroxyl groups of Eudragit® with α-GOS was not detected. By TG and DSC, it was possible to detect that there were no changes in the thermal properties between the proposed combinations and the standard film. Upon SEM analysis, the appearance of pores for the association 90:10 was evidenced. Possibly, these pores act as output ports for the drug. These results sharpen the perspective of applying this material to the coating of pharmaceutical formulations of modified drug delivery.
本研究旨在通过应用傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、热重分析法（TG）和扫描电子显微镜（SEM）等物理化学分析方法，分析掺入α-低聚葡萄糖（GOS-α）对不同聚甲基组合的隔离膜形成的影响。通过将Eudragit® RS30D与α-GOS结合蒸发制备聚合物膜。FTIR结果证实了α-GOS的掺入。未检测到Eudragit®的羰基和羟基与α-GOS之间的分子间相互作用。通过TG和DSC，可以检测到所提出的组合与标准膜之间的热性能没有变化。通过SEM分析，证实了90:10组合存在孔隙。这些孔隙可能作为药物的输出端口。这些结果拓宽了将该材料应用于药物递送修饰的药物制剂包衣的前景。
