脑脊液中未检测到HIV与检测到HIV但低于20拷贝/毫升的成年HIV感染者的中枢神经系统损伤标志物
Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL.
作者信息
Farhadian Shelli F, Mistry Hetal, Kirchwey Tobias, Chiarella Jennifer, Calvi Rachela, Chintanaphol Michelle, Patel Payal, Landry Marie L, Robertson Kevin, Spudich Serena S
机构信息
Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
出版信息
Open Forum Infect Dis. 2019 Dec 14;6(12):ofz528. doi: 10.1093/ofid/ofz528. eCollection 2019 Dec.
The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood-brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.
在抗逆转录病毒治疗（ART）期间，脑脊液（CSF）中可量化的HIV RNA的存在可能与中枢神经系统（CNS）病理学相关，但在ART期间标准检测中检测到的低于定量下限（LOQ）的RNA的意义仍不明确。我们比较了脑脊液RNA检测低于LOQ（20拷贝/毫升）的个体与未检测到HIV RNA的个体之间的中枢神经系统参数。脑脊液HIV RNA的检测与血脑屏障完整性降低和执行功能下降有关，但与中枢神经系统免疫激活或整体神经心理学测试中的较差表现无关。
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