近红外光谱测量新生儿脑损伤自发氧合变化的脑血流。
Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury.
机构信息
Medical Physics and Biomedical Engineering, University College London, London, UK.
Institute for Women's Health, University College London, London, UK.
出版信息
Adv Exp Med Biol. 2020;1232:3-9. doi: 10.1007/978-3-030-34461-0_1.
Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick's principle and uses HbD as a tracer; when a sudden change in SaO occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g min with a range of 4 ml 100 g min to 60 ml 100 g min. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth.
在新生儿重症监护病房中，使用宽带近红外光谱（NIRS）系统监测患有缺氧缺血性（HI）脑损伤的新生儿。本研究旨在利用 NIRS 脑氧合数据（HbD=氧合血红蛋白-去氧血红蛋白）和脉搏血氧饱和度 SaO 计算脑血流量（CBF），方法是基于氧摆动法，在自发性氧饱和度降低期间进行计算。该方法基于 Fick 原理，使用 HbD 作为示踪剂；当 SaO 突然发生变化时，HbD 的变化代表示踪剂浓度的变化，因此可以估计 CBF。在出生当天，用宽带 NIRS 成功计算了 11 例 HIE 婴儿（3 例严重损伤）70 次氧合事件的 CBF。平均 CBF 为 18.0±12.7ml/100g/min，范围为 4ml/100g/min 至 60ml/100g/min。对于磁共振波谱检查确定为严重 HIE 的婴儿，出生当天的 CBF 明显低于中度 HIE 婴儿（p=0.038，d=1.35）。
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