Division of Epidemiology and Biostatistics, University of Illinois At Chicago School of Public Health, 1603 W. Taylor Street, MC 923, Chicago, IL, 60612, USA.
University of Illinois At Chicago College of Pharmacy, 833 S. Wood St, Chicago, IL, 60612, USA.
AIDS Behav. 2020 Jul;24(7):2130-2148. doi: 10.1007/s10461-020-02779-4.
We conducted a systematic review and meta-analysis to estimate the prevalence of adherence to antiretroviral therapy (ART) in India, the third largest HIV epidemic in the world. We identified peer reviewed literature published between 2007 and 2017 to extract data on ART adherence. We estimated pooled prevalence of adherence to ART using a random-effects model. Thirty-two eligible studies (n = 11,543) were included in the meta-analysis. Studies were mostly clustered in the southern and western Indian states. Overall, 77% (95% Confidence Interval 73-82; I = 96.80%) of patients had optimum adherence to ART. Women had higher prevalence of optimum adherence compared to men. Depression or anxiety were significant risk factors in seven of the fifteen studies reporting determinants of nonadherence. Studies should be performed to explore the reasons for gender gap in ART adherence and HIV program in India should prioritize mental health issues among HIV patients to improve ART adherence.
我们进行了一项系统评价和荟萃分析，以估计印度抗逆转录病毒疗法（ART）的依从率，印度是世界上第三大艾滋病毒流行地区。我们确定了 2007 年至 2017 年期间发表的同行评审文献，以提取有关 ART 依从性的数据。我们使用随机效应模型估计了 ART 依从性的汇总流行率。荟萃分析纳入了 32 项符合条件的研究（n=11543）。这些研究主要集中在印度南部和西部各州。总体而言，77%（95%置信区间 73-82；I=96.80%）的患者对 ART 具有最佳的依从性。与男性相比，女性具有更高的最佳依从性的患病率。在报告非依从性决定因素的 15 项研究中的 7 项中，抑郁或焦虑是显著的危险因素。应开展研究，以探讨在印度，ART 依从性方面存在性别差距的原因，印度的 HIV 规划应优先考虑 HIV 患者的心理健康问题，以提高 ART 依从性。
