Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, 1 Debinki, 80-211 Gdansk, Poland.
Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Nutrients. 2020 Jan 9;12(1):187. doi: 10.3390/nu12010187.
One-anastomosis gastric bypass is a promising type of bariatric surgery, but it may lead to a deficiency in important nutrients, such as fatty acids. The short-term effects of one-anastomosis gastric bypass on serum fatty acids have not been studied thus far. Therefore, the aim of this study was to determine the effect of one-anastomosis gastric bypass on serum fatty acid composition two weeks after surgery. This study included 38 patients who underwent one-anastomosis gastric bypass as surgical treatment for morbid obesity. Serum fatty acid composition was analyzed before and two weeks after surgery using gas chromatography-mass spectrometry. We observed a decrease in essential polyunsaturated fatty acids ( < 0.001 for linolenic acid and < 0.001 for linoleic acid) and odd-chain fatty acids ( = 0.004) in the serum of obese patients shortly after a one-anastomosis gastric bypass. Considering the benefits of the aforementioned fatty acids for human health, the implementation of a fatty-acid-rich diet or the use of supplementation may be recommended for patients immediately after one-anastomosis gastric bypass.
单吻合口胃旁路术是一种有前途的减肥手术类型，但它可能导致重要营养素（如脂肪酸）的缺乏。单吻合口胃旁路术后对血清脂肪酸的短期影响迄今尚未研究。因此，本研究旨在确定单吻合口胃旁路术对肥胖患者术后两周血清脂肪酸组成的影响。这项研究包括 38 名接受单吻合口胃旁路术的患者，作为病态肥胖的手术治疗方法。使用气相色谱-质谱法在术前和术后两周分析血清脂肪酸组成。我们观察到肥胖患者在单吻合口胃旁路术后不久，必需多不饱和脂肪酸（亚油酸 < 0.001，亚麻酸 < 0.001）和奇数链脂肪酸（= 0.004）的血清水平下降。考虑到上述脂肪酸对人类健康的益处，建议在单吻合口胃旁路术后立即为患者提供富含脂肪酸的饮食或使用补充剂。
