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特利加压素治疗肝硬化腹水相关并发症的研究进展

[Research progress of terlipressin in the treatment of cirrhotic ascites-related complications].

作者信息

Liu C H, Xing F, Wang J

机构信息

Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2019 Dec 20;27(12):929-932. doi: 10.3760/cma.j.issn.1007-3418.2019.12.005.

Abstract

Ascites is the most common clinical symptom in the decompensated stage of patients with liver cirrhosis, and its co-existence in complex conditions, such as refractory ascites, hyponatremia, hepatorenal syndrome and other complications may harm seriously. Splanchnic vasodilation is the key pathological link of cirrhotic ascites-related complications and the treatment of this link can help to eliminate the symptoms of ascites and prevent the further deterioration of decompensated cirrhosis. This paper summaries the pharmacological basis, clinical evidence and application characteristics of a vasocative drugs-terlipressin in the treatment of cirrhotic ascites-related complications, and further analyzes the problems existing in the current research, then proposes a prospect.

摘要

腹水是肝硬化患者失代偿期最常见的临床症状,其与难治性腹水、低钠血症、肝肾综合征等复杂情况并存时,可能会造成严重危害。内脏血管扩张是肝硬化腹水相关并发症的关键病理环节,针对这一环节进行治疗有助于消除腹水症状,防止失代偿期肝硬化进一步恶化。本文综述了血管活性药物特利加压素治疗肝硬化腹水相关并发症的药理基础、临床证据及应用特点,进一步分析了当前研究中存在的问题,并提出了展望。

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