从血凝素的阴影中浮现：神经氨酸酶是流感疫苗接种的重要靶点。
Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination.
机构信息
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.
出版信息
Cell Host Microbe. 2019 Dec 11;26(6):712-713. doi: 10.1016/j.chom.2019.11.006.
Gilchuk et al. (2019) and Zhu et al. (2019) provide detailed structural information about epitopes on influenza virus N9 neuraminidase and characterize breadth, potency, mechanism of action, and in vivo protective effects of human antibodies targeting these epitopes. The findings highlight the importance of neuraminidase as a target for improved influenza virus vaccines.
吉尔楚克等人（2019 年）和朱等人（2019 年）提供了有关流感病毒 N9 神经氨酸酶表位的详细结构信息，并描述了针对这些表位的人类抗体的广度、效力、作用机制和体内保护效果。这些发现强调了神经氨酸酶作为改进流感病毒疫苗的靶标的重要性。
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