Rogausch H
Department of Physiology, Philipps-Universität, Marburg/Lahn, Fed. Rep. of Germany.
Arzneimittelforschung. 1988 Oct;38(10):1478-81.
Normal biconcave erythrocytes were transformed by the lysolipid lysolecithin (1-alpha-lysophosphatidylcholine, LPC) into spiculated and sphered corpuscles which had a normal viscosity at high shear rates despite their abnormal shape. The LPC induced a hitherto not identified metabolic process within the erythrocyte which depended on various factors as the Ca++-concentration, pH-value, and temperature of the suspending medium and which was advanced by guanosine or certain drugs as for instance moxaverine, a derivative of papaverine. This metabolic process normalized transiently the erythrocyte shape and deformability; but the cells started to become more viscous again during longer incubation though their shape remained normal. Because the shape of red cells correlated weakly with their deformability, it is suggested that measurements of the mechanical properties of erythrocytes should supplement the morphological studies in investigations of drugs which affect the red cell shape.
正常的双凹红细胞被溶血磷脂溶血卵磷脂（1-α-溶血磷脂酰胆碱，LPC）转化为有刺突和球形的细胞，尽管其形状异常，但在高剪切速率下具有正常的粘度。LPC在红细胞内诱导了一个迄今未被识别的代谢过程，该过程取决于多种因素，如悬浮介质中的钙离子浓度、pH值和温度，并且被鸟苷或某些药物（如罂粟碱衍生物莫沙维林）所促进。这个代谢过程使红细胞的形状和变形能力暂时恢复正常；但在较长时间的孵育过程中，细胞再次开始变得更粘稠，尽管它们的形状保持正常。由于红细胞的形状与其变形能力的相关性较弱，因此建议在研究影响红细胞形状的药物时，红细胞力学性能的测量应补充形态学研究。
