早期限时剖宫产儿产前使用皮质类固醇的并发症。
Complications of Antenatal Corticosteroids in Infants Born by Early Term Scheduled Cesarean Section.
机构信息
Macarthur Diabetes Service, Campbelltown Hospital, Campbelltown, New South Wales, Australia.
Macarthur Clinical School, Western Sydney University, Campbelltown, New South Wales, Australia.
出版信息
Diabetes Care. 2020 Apr;43(4):906-908. doi: 10.2337/dc19-2126. Epub 2020 Jan 23.
OBJECTIVE
To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration.
RESEARCH DESIGN AND METHODS
In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia.
RESULTS
NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, = 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, = 0.209) following corticosteroid administration.
CONCLUSIONS
Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.
目的
比较患有糖尿病的孕妇行早期择期剖宫产（ETSCS）时，使用和不使用皮质类固醇激素进行分娩，新生儿低血糖和呼吸系统发病率的差异。
研究设计和方法
本回顾性队列研究纳入了所有行 ETSCS 的妊娠期糖尿病患者。主要结局为因呼吸窘迫综合征（RDS）/新生儿暂时性呼吸急促（TTN）和/或新生儿低血糖而入住新生儿重症监护病房（NICU）的发生率。
结果
皮质类固醇激素组新生儿低血糖的 NICU 入住率明显更高（24.2% vs. 4.4%， = 0.003），RDS/TTN 发生率虽略有升高但无统计学意义（15.2% vs. 7.2%， = 0.209）。
结论
皮质类固醇激素对妊娠期患有任何类型糖尿病而进行 ETSCS 的女性无益，甚至可能有害。在我们医院，我们已经停止在这种情况下对女性使用皮质类固醇激素。
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