干扰素 lambda 1 与泰国登革热严重程度相关。
Interferon lambda 1 is associated with dengue severity in Thailand.
机构信息
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Bangkok 10400, Thailand.
Laboratory of Human Genome Diversity, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Int J Infect Dis. 2020 Apr;93:121-125. doi: 10.1016/j.ijid.2020.01.026. Epub 2020 Jan 22.
OBJECTIVES
Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS). This study was performed to determine the host genetic factors responsible for dengue severity. Two single nucleotide polymorphisms (SNPs) of the interferon lambda 1 (IFNL1) gene (rs30461 and rs7247086) were analyzed for their association with dengue severity in a Thai population.
METHODS
This was a case-control association study involving 877 patients under the age of 15 years (DF, n = 386; DHF, n = 416; DSS, n = 75). Genotyping was performed by TaqMan real-time PCR assay.
RESULTS
It was found that the rs7247086 variant of IFNL1 was associated with DHF, but not DSS. Genotypes CT and TT and the T allele were protective against DHF (p = 0.03, odds ratio 0.62 for CT, odds ratio 0.13 for TT; and p = 0.01, odds ratio 0.54 for the T allele). The other SNP tested was not associated with DHF or DSS.
CONCLUSIONS
The rs7247086 variant of IFNL1 (the T allele) was found to be protective against DHF, suggesting that IFNL1 may play a role in the pathogenesis of DHF.
目的
登革热患者表现出从急性发热疾病（登革热，DF）到登革出血热（DHF），再到最严重的结果，登革休克综合征（DSS）等多种症状。本研究旨在确定导致登革热严重程度的宿主遗传因素。分析干扰素 lambda 1（IFNL1）基因的两个单核苷酸多态性（SNP）（rs30461 和 rs7247086）与泰国人群登革热严重程度的相关性。
方法
这是一项病例对照关联研究，涉及 877 名年龄在 15 岁以下的患者（DF，n=386；DHF，n=416；DSS，n=75）。采用 TaqMan 实时 PCR 法进行基因分型。
结果
发现 IFNL1 的 rs7247086 变体与 DHF 相关，但与 DSS 无关。CT 和 TT 基因型和 T 等位基因对 DHF 具有保护作用（p=0.03，CT 的优势比为 0.62，TT 的优势比为 0.13；p=0.01，T 等位基因的优势比为 0.54）。测试的另一个 SNP 与 DHF 或 DSS 均无关。
结论
IFNL1 的 rs7247086 变体（T 等位基因）被发现对 DHF 具有保护作用，表明 IFNL1 可能在 DHF 的发病机制中发挥作用。
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