HSD11B1 和 HSD11B2 的相互调节预测儿童急性淋巴细胞白血病的糖皮质激素敏感性。
Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
机构信息
Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK; Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan.
Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK; Division of Developmental Biology, The Roslin Institute, The University of Edinburgh, Edinburgh, UK.
出版信息
J Pediatr. 2020 May;220:249-253. doi: 10.1016/j.jpeds.2019.12.054. Epub 2020 Jan 24.
There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11β-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.
目前几乎没有生物标志物可以预测儿童急性淋巴细胞白血病（ALL）在诊断时对糖皮质激素治疗的疗效。在这里，我们证明了 11β-羟类固醇脱氢酶（11β-HSD）的相互调节可能预测 ALL 对糖皮质激素治疗的凋亡反应。我们的数据可能有助于完善糖皮质激素治疗方案，在最小化副作用的同时保留疗效。
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